| 666794 | D3Z4I3 | RBM24_MOUSE | RNA-binding protein 24 (RNA-binding motif protein 24) | DISRUPTION PHENOTYPE | Mice die in utero between embryonic days 12.5 and 14.5 (PubMed:25313962, PubMed:29358667). Show multiple cardiac malformations, including defective endocardial cushion morphogenesis, ventricular septum defects, reduced trabeculation and compaction and dilated atria (PubMed:25313962, PubMed:29358667). Display loss of sarcomeres in cardiomyocytes (PubMed:25313962). Show aberrant pre-mRNA alternative splicing of key genes necessary for sarcomere formation and cardiogenesis (PubMed:25313962). {ECO:0000269|PubMed:25313962, ECO:0000269|PubMed:29358667}. |