| 66824 | Q9EPB4 | ASC_MOUSE | Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein) | DISRUPTION PHENOTYPE | Increased resistance to endotoxic shock and severe defects in caspase-1 activation and interleukin-1 beta and interleukin-18 production in macrophages in response to several pro-inflammatory molecules (PubMed:15190255, PubMed:15507117). Mutants are resitant to vaccinia virus (VACV) but not vesicular somatitis virus (VSV) infection. They show lower viral loads in the lungs compared to wild type mice, they produce higher levels of type I IFN, IL6 and RSAD2/Viperin after VCAV INFECTION (PubMed:28314590). {ECO:0000269|PubMed:15190255, ECO:0000269|PubMed:15507117, ECO:0000269|PubMed:28314590}. |