Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:67133
  • Symbol:Gp2
  • Description:glycoprotein 2 (zymogen granule membrane)
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Gene ID Entry Entry Name Protein Name Type Information
67133 Q9D733 GP2_MOUSE Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) DISRUPTION PHENOTYPE Knockout mice lacking Gp2 fail to induce antigen-specific helper-T-cells and antibody immune responses after oral immunization with FimH positive bacteria (PubMed:19907495). This is not due to a general defect in the immunological functions, since a normal response is induced by other systemic immunizations (PubMed:19907495). {ECO:0000269|PubMed:19907495}.