Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:67345
  • Symbol:Herc4
  • Description:hect domain and RLD 4
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Gene ID Entry Entry Name Protein Name Type Information
67345 Q6PAV2 HERC4_MOUSE Probable E3 ubiquitin-protein ligase HERC4 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 4) (HECT-type E3 ubiquitin transferase HERC4) DISRUPTION PHENOTYPE Disruption causes defects in spermatozoon maturation and impaired fertility in males; females display normal fertility. Males produce litter sizes some 50% smaller, as well 50% of mature spermatozoa have reduced mobility. {ECO:0000269|PubMed:17967448}.