Gene ID | Entry | Entry Name | Protein Name | Type | Information | 67345 | Q6PAV2 | HERC4_MOUSE | Probable E3 ubiquitin-protein ligase HERC4 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 4) (HECT-type E3 ubiquitin transferase HERC4) | DISRUPTION PHENOTYPE | Disruption causes defects in spermatozoon maturation and impaired fertility in males; females display normal fertility. Males produce litter sizes some 50% smaller, as well 50% of mature spermatozoa have reduced mobility. {ECO:0000269|PubMed:17967448}. |
---|