| 67374 | Q9JI59 | JAM2_MOUSE | Junctional adhesion molecule B (JAM-B) (Junctional adhesion molecule 2) (JAM-2) (Vascular endothelial junction-associated molecule) (VE-JAM) (CD antigen CD322) | DISRUPTION PHENOTYPE | Mice lacking Jam2 do not display overt morphological, vascular or immunologic phenotype (PubMed:21868569). However, aberrant myelination of dorsal horn interneuron cell bodies is observed (PubMed:27499083, PubMed:21868569). They develop age-dependent significant walking and gait abnormalities compared to controls. Neuropathologic brain analysis show age-dependent progressive prominent vacuolization in the midbrain, thalamus, and cerebral and cerebellar cortices. These changes are associated with reactive astrogliosis, microglial activation, and a reduced neuronal density. Similar findings are observed in spinal cord sections. There is no evidence of mineralization or calcification in the brain or spinal cord of mutant mice (PubMed:32142645). {ECO:0000269|PubMed:21868569, ECO:0000269|PubMed:27499083, ECO:0000269|PubMed:32142645}. |