| 67772 | Q09XV5 | CHD8_MOUSE | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Axis duplication inhibitor) (Duplin) | DISRUPTION PHENOTYPE | Death during early embryogenesis due to widespread apoptosis. Embryos manifest growth retardation from 5.5 dpc and developmental arrest accompanied by massive apoptosis at 7.5 dpc. They develop into an egg cylinder but do not form a primitive streak or mesoderm. Mice lacking both Tp53 and Chd8 ameliorate this developmental arrest. {ECO:0000269|PubMed:15367660, ECO:0000269|PubMed:19151705}. |