68703 | Q80TZ9 | RERE_MOUSE | Arginine-glutamic acid dipeptide repeats protein (Atrophin-2) | DISRUPTION PHENOTYPE | Mice embryos exhibit a variety of patterning defects that first appear at 8.0 dpc. Defects include a specific failure in ventralization of the anterior neural plate, loss of heart looping and irregular partitioning of somites. In mutant embryos, Shh expression fails to initiate along the anterior midline at 8.0 dpc, and Fgf8 is delocalized from the anterior neural ridge at 8.5 dpc. {ECO:0000269|PubMed:14645126}. |