| 70584 | Q8BTW9 | PAK4_MOUSE | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | DISRUPTION PHENOTYPE | Mice die at embryonic day 11.5 probably due to a defect in the fetal heart. They show strong defects in neuronal development and axonal outgrowth. Spinal cord motor neurons and interneurons failed to differentiate and migrate to their proper position. Nervous system-specific conditional PAK4 deletion mice display growth retardation and die prematurely. {ECO:0000269|PubMed:14517283, ECO:0000269|PubMed:21382368}. |