| 71461 | Q8BKG3 | PTK7_MOUSE | Inactive tyrosine-protein kinase 7 (Protein chuzhoi) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7) | DISRUPTION PHENOTYPE | Mice die perinatally and display craniorachischisis, a severe form of neural tube defect in which the neural tube fails to close from the midbrain hindbrain boundary to the base of the spine. Chuzhoi mutants also display disruption of planar cell polarity in the inner ear, and defective heart and lung development. {ECO:0000269|PubMed:15229603, ECO:0000269|PubMed:19439496, ECO:0000269|PubMed:20704721}. |