| 71609 | Q3U0V2 | TRADD_MOUSE | Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain) | DISRUPTION PHENOTYPE | Mice develop tumors. In a C57BL/6 genetic background, mice exhibit a shorter lifespan than wild-type, but exhibit low incidences of observable tumor formation. In the FVB/N background, which is more tumor-prone, mice show a significant increas in the spontaneous development of a broad range of tumor types. {ECO:0000269|PubMed:22561347}. |