| 73750 | Q80VW5 | WHRN_MOUSE | Whirlin | DISRUPTION PHENOTYPE | Mutant mice for isoform 1 appear viable and comparable to their wild-type littermates in growth characteristics, reproductive performance and general health (PubMed:20502675). At 2 and 9 months of age, knockouts show a profound hearing loss across all cochlear frequencies (PubMed:20502675). At 28 to 33 months, they show signs for retinal degeneration such as a thinner photoreceptor nuclear layer and outer segments shortened (PubMed:20502675). {ECO:0000269|PubMed:20502675}. |