| 74407 | Q9D4B2 | ODAD4_MOUSE | Outer dynein arm-docking complex subunit 4 (Tetratricopeptide repeat protein 25) (TPR repeat protein 25) | DISRUPTION PHENOTYPE | Heterozygous intercrosses reveal deviation from the Mendelian distribution, with only 6 homozygous out of 53 born mice, suggesting increased death in utero. Most surviving homozygous mice present with small body size, some with hydrocephalus at the age of 2 weeks. They display a variety of left-right body asymmetry defects, including reversal of lung lobation or dextrocardia. At the cell level, the trachea and fallopian tubes of mutant animals show absence of outer dynein arms from the ciliary axonemes, and consequently severe reduction of cilia beating. There is no evidence of short cilia or a reduction in cilia number. {ECO:0000269|PubMed:27486780}. |