| 74769 | Q8BTI9 | PK3CB_MOUSE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (P | DISRUPTION PHENOTYPE | Mice have defects in autophagosome formation. Have normal bleeding time but are resistant to thrombosis after arterial injury. Mice fail to induce tumors in a model of prostate tumor formation induced by Pten loss. {ECO:0000269|PubMed:18594509, ECO:0000269|PubMed:19515725, ECO:0000269|PubMed:20065293, ECO:0000269|PubMed:21059846}. |