| 78560 | Q91ZV8 | AGRA2_MOUSE | Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5) | DISRUPTION PHENOTYPE | No viable adults (PubMed:21071672, PubMed:21282641, PubMed:21421844). Beginning at 11 dpc, deficient embryos exhibit completely penetrant, progressive CNS hemorrhage originating in forebrain telencephalon and ventral neural tube leading to embryonic lethality from 15.5 dpc (PubMed:21071672, PubMed:21282641, PubMed:21421844). Embryos at 11.5 dpc display selective CNS-specific vascular patterning defects, with markedly reduced angiogenic sprouting into the forebrain telencephalon and thickening of the underlying periventricular vascular plexus rendering the telencephalon virtually avascular (PubMed:21071672, PubMed:21282641, PubMed:21421844, PubMed:25373781). Remaining CNS vessels show significantly increased permeability (PubMed:21421844). Lung size is reduced in 15.5 dpc embryos (PubMed:21282641). Cleft palate is present at 15.5 dpc or later (PubMed:21282641). Conditional knockout mice lacking Adgra2 in the endothelia of adult mice show blood-brain barrier integrity defects in a stroke model and glioblastoma (PubMed:28288111). {ECO:0000269|PubMed:21071672, ECO:0000269|PubMed:21282641, ECO:0000269|PubMed:21421844, ECO:0000269|PubMed:25373781, ECO:0000269|PubMed:28288111}. |