| 83456 | Q99MV5 | M10L1_MOUSE | RNA helicase Mov10l1 (EC 3.6.4.13) (Cardiac helicase activated by MEF2 protein) (Cardiac-specific RNA helicase) (Moloney leukemia virus 10-like protein 1 homolog) (MOV10-like protein 1 homolog) | DISRUPTION PHENOTYPE | Mice are viable and healthy but show male sterility due to defects in spermatogenesis at early prophase of meiosis I (PubMed:20534472, PubMed:20547853, PubMed:23166510). Retrotransposons are derepressed due to DNA demethylation (PubMed:20534472). Defects are caused by impaired piRNA biogenesis during pachytene (PubMed:20534472, PubMed:20547853). The absence of pachytene piRNAs causes disruption of germ cell development and results in defects in post-meiotic genome integrity (PubMed:23166510). Mice do not show any cardiac abnormalities (PubMed:20547853). {ECO:0000269|PubMed:20534472, ECO:0000269|PubMed:20547853, ECO:0000269|PubMed:23166510}. |