Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:83964
  • Symbol:Jam3
  • Description:junction adhesion molecule 3
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Gene ID Entry Entry Name Protein Name Type Information
83964 Q9D8B7 JAM3_MOUSE Junctional adhesion molecule C (JAM-C) (JAM-2) (Junctional adhesion molecule 3) (JAM-3) [Cleaved into: Soluble form of JAM-C (sJAM-C)] DISRUPTION PHENOTYPE Important mortality during the postnatal period; about 40% of the mutant mice survive. Mutant males are infertile; they have strongly reduced testis size and fail to produce mature sperm cells. Developing spermatids fail to become polarized, and do not form acrosomes. {ECO:0000269|PubMed:15372036}.