| 852861 | P53191 | PIB2_YEAST | Glutamine sensor PIB2 (Phosphatidylinositol 3-phosphate-binding protein 2) | DISRUPTION PHENOTYPE | Abnormal activation of TORC1 signaling in nitrogen-replete conditions (glutamine or leucine nitrogen source), and during high hydrostatic pressure (mechanical stress) (PubMed:28993463, PubMed:29698392, PubMed:28483912, PubMed:32801125). Increases cellular levels of glutamine and alanine during high hydrostatic pressure (mechanical stress) (PubMed:32801125). Sensitive to rapamycin (TORC1 signaling-inhibitor), caffeine, and high hydrostatic pressure (mechanical stress) (PubMed:28993463, PubMed:29698392, PubMed:34535752, PubMed:26510498, PubMed:32801125). Abnormal TORC1-reactivation following inactivaton by rapamycin (TORC1 signaling-inhibitor) (PubMed:28993463). Resistance to tunicamycin (endoplasmic reticulum stressor) administered together with FK506 (calcineurin inhibitor) (PubMed:26510498). Abnormal localization of TOR1 to vacuoles (PubMed:28993463). Localization of GTR1 and GTR2 to vacuoles is normal (PubMed:28993463) Localization of TORC1 to vacuoles is normal (PubMed:28483912). Simultaneous disruption of GTR1 results in TOR1 mislocalization and loss of TORC1 activity and viability (PubMed:29698392). Simultaneous disruption of EGO1 results in loss of viability (PubMed:29698392). Macroautophagy appears normal (PubMed:28993463). {ECO:0000269|PubMed:26510498, ECO:0000269|PubMed:28483912, ECO:0000269|PubMed:28993463, ECO:0000269|PubMed:29698392, ECO:0000269|PubMed:32801125, ECO:0000269|PubMed:34535752}. |