| Gene ID | Entry | Entry Name | Protein Name | Type | Information | 854053 | Q12236 | PKH2_YEAST | Serine/threonine-protein kinase PKH2 (EC 2.7.11.1) (PKB-activating kinase homolog 2) | DISRUPTION PHENOTYPE | Long-term depletion of PKH2 in a PKH1 null mutant (Pkh depletion) induces programmed cell death. This is mediated by the lack of Pkh-dependent activation of the PKC1 downstream signaling cascade and results in accumulation of reactive oxigen species (ROS) and DNA fragmentation. {ECO:0000269|PubMed:23911092}. |
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