| 171647 | Q9N2Z7 | WWP1_CAEEL | E3 ubiquitin-protein ligase wwp-1 (EC 2.3.2.26) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown increases sensitivity to paraquat, and reduces lifespan at 25 degrees Celsius, but not at 20 degrees Celsius (PubMed:19553937). Causes reduced ability of dietary restriction to extend lifespan (PubMed:24805825, PubMed:19553937). Abolishes lifespan extension completely on an eat-2 mutant background, independent of whether knockdown is ubiquitous, or targeted only to the intestine (PubMed:24805825, PubMed:19553937). Does not suppress extended lifespans of isp-1 or daf-2 mutants (PubMed:19553937). Hypersensitive to bacterial pore-forming toxin (PubMed:20209166). {ECO:0000269|PubMed:19553937, ECO:0000269|PubMed:20209166, ECO:0000269|PubMed:24805825}. |