Mine Disruption Phenotype

Gene Info

  • Species:Worm (Caenorhabditis elegans)
  • GeneID:171722
  • Symbol:src-1
  • Description:Tyrosine protein-kinase src-1
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Gene ID Entry Entry Name Protein Name Type Information
171722 G5EE56 SRC1_CAEEL Tyrosine protein-kinase src-1 (EC 2.7.10.2) (SRC oncogene related protein 1) DISRUPTION PHENOTYPE RNAi-mediated knockdown causes a growth arrest between gastrulation and the 2-fold stage and an increase in number of apoptotic cell corpses at the comma and 1.5-fold stages (PubMed:12527374, PubMed:16024786, PubMed:20226672). The few hermaphrodite animals reaching adulthood have gonadal defects characterized by the formation of a straight gonad resulting from defects in distal tip cells migration during the first and second turns (PubMed:16251208, PubMed:16024786). {ECO:0000269|PubMed:12527374, ECO:0000269|PubMed:16024786, ECO:0000269|PubMed:16251208, ECO:0000269|PubMed:20226672}.