| 171915 | Q9N3T5 | AFG3_CAEEL | AFG3-like protein spg-7 (EC 3.4.24.-) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype) (PubMed:21408209). RNAi-mediated knockdown induces nuclear and mitochondrial transcription of mitochondrial protective genes including chaperone hsp-60 as part of the mitochondrial unfolded protein response (PubMed:25773600, PubMed:25274306, PubMed:22700657). RNAi-mediated knockdown causes nuclear accumulation of transcription factor atfs-1 in intestinal cells (PubMed:22700657). RNAi-mediated knockdown results in mitochondria in intestinal cells which are abnormally elongated (PubMed:25274306). RNAi-mediated knockdown reduces oxygen consumption (PubMed:25773600). RNAi-mediated knockdown also induces the transcription of innate immunity-related genes such as lys-2, abf-2, clec-65 and clec-4 which results in resistance to P.aeruginosa-mediated infection (PubMed:25274306). RNAi-mediated knockdown abolishes transcription up-regulation in an atfs-1 (tm4919) mutant background (PubMed:22700657, PubMed:25274306, PubMed:25773600). {ECO:0000269|PubMed:21408209, ECO:0000269|PubMed:22700657, ECO:0000269|PubMed:25274306, ECO:0000269|PubMed:25773600}. |