| 172077 | Q9U7E0 | ATRX_CAEEL | Transcriptional regulator ATRX homolog (EC 3.6.4.12) (ATP-dependent helicase xnp-1) (X-linked nuclear protein 1) | DISRUPTION PHENOTYPE | Temperature-sensitive with 38% embryonic lethality at 25 degrees Celsius (PubMed:15649460). A large proportion of surviving animals are sterile. Surviving animals also have gonad developmental defects such as defective gonadal arm growth and as a result irregular distal tip cell migration, and 24% of animals had a protruding vulva phenotype (PubMed:15649460). Reduced brood size (PubMed:15328017). Double knockout with lin-35 results in 43% embryonic lethality (PubMed:15328017). Surviving animals develop slowly, are small, sterile and display male and female gonad developmental defects characterized by shorter gonadal arms, fewer germ cells, an everted vulva phenotype, and failed formation of sheath and spermathecal cells (PubMed:15328017). RNAi-mediated knockdown of lin-35 or hpl-2 results in larval arrest at 25 degrees Celsius in an xpn-1 mutant background (PubMed:15649460). {ECO:0000269|PubMed:15328017, ECO:0000269|PubMed:15649460}. |