| 172280 | Q9TXI7 | PK3C3_CAEEL | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (EC 2.7.1.137) (Phosphoinositide-3-kinase class 3) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown causes a defect in the clearance of apoptotic cell corpses in gonads, a loss of rab-5 recruitment to cell corpse-containing nascent phagosomes and a decrease in PI3P levels on phagosome membranes (PubMed:18425118, PubMed:22272187). In addition, causes a reduction in mig-14 and rme-8 association with puncta structures as well as an increase in mig-14 protein levels (PubMed:21183797). RNAi-mediated knockdown results in reduced germ stem cell proliferation during larval development (PubMed:28285998). {ECO:0000269|PubMed:18425118, ECO:0000269|PubMed:21183797, ECO:0000269|PubMed:22272187, ECO:0000269|PubMed:28285998}. |