| 172434 | G5EFF7 | UBQL_CAEEL | Ubiquilin | DISRUPTION PHENOTYPE | RNAi-mediated knockdown causes a reduction in lifespan (PubMed:19822669). Induces ER stress characterized by the expression of hsp-4, the accumulation of ubiquitinated proteins and an increase in ubxn-4 expression (PubMed:19822669). Mutants display increased homologous recombination repair in response to DNA damage compared to wild-type worms (PubMed:30612738). Worms lacking both POST (F36D4.5) and ubql-1 have a shorter lifespan and display an accumulation of ubiquitinated proteins in the nucleus (PubMed:29666234). {ECO:0000269|PubMed:19822669, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}. |