| 172552 | G5EF68 | TAF5_CAEEL | Transcription initiation factor TFIID subunit 5 (TBP-associated transcription factor family member taf-5) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown causes arrested development at 90-100 cells and inhibits differentiation (PubMed:12458202). The two E cell daughters (E2 cells), which form the endoderm, divide abnormally early (PubMed:12458202). Phosphorylation of the RNA Pol II large subunit C-terminal domain (CTD) is reduced significantly in embryos (PubMed:12458202). Reduces expression of a range of genes, including let-858, rps-5, hsp16.2, and pes-10, but has little or no effect on expression of cki-2 and sur-5 (PubMed:12458202). Has little or no effect on levels of the TFIID subunits taf-10 and taf-4 (PubMed:12458202). {ECO:0000269|PubMed:12458202}. |