| 172586 | Q21222 | AFG2H_CAEEL | ATPase family protein 2 homolog (EC 3.6.4.10) (Cell division cycle-related protein 48.3) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown causes embryonic lethality (PubMed:15716356, PubMed:18854144). The first embryonic cell divisions have mitotic spindle and chromosome segregation defects, and mitotic progression is significantly delayed (PubMed:18854144). At late telophase/G1, air-2 accumulates at the spindle midbody abnormally persisting following cleavage furrow ingression and into the next mitotic cycle (PubMed:18854144). Loss of inhibition of air-2 kinase activity (PubMed:18854144). Also, causes defects in ER dynamics characterized by a failure of the ER to form a sheet structure at the onset of mitosis and remains in large aggregates throughout mitosis (PubMed:15716356). In an air-2 (os207) mutant background, which lacks air-2 catalytic activity, restores normal mitosis and thus embryonic viability (PubMed:18854144). {ECO:0000269|PubMed:15716356, ECO:0000269|PubMed:18854144}. |