| 172591 | Q21227 | APR1_CAEEL | Adenomatous polyposis coli protein-related protein 1 (APC-related protein 1) | DISRUPTION PHENOTYPE | Worms exhibit lack of endoderm, excessive pharyngeal tissue and premature division of the E daughter blastomeres during embryogenesis. Two-thirds arrest during embryogenesis and the remaining third during the L1 stage (PubMed:9288750). RNAi-mediated knockdown causes partial nuclear re-localization of hmp-2 in the embryonic epidermis and the production of supernumerary gut nuclei probably resulting from epithelial cell hyperproliferation (PubMed:20805471). {ECO:0000269|PubMed:20805471, ECO:0000269|PubMed:9288750}. |