Mine Disruption Phenotype

Gene Info

  • Species:Worm (Caenorhabditis elegans)
  • GeneID:172628
  • Symbol:sin-3
  • Description:Paired amphipathic helix protein sin-3
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Gene ID Entry Entry Name Protein Name Type Information
172628 A5JYW9 SIN3_CAEEL Paired amphipathic helix protein sin-3 (Histone deacetylase complex subunit sin-3) (Transcriptional corepressor sin-3) DISRUPTION PHENOTYPE Uncoordinated movement, protruding vulva and ray fusion defects in the male tail (PubMed:17506990). RNAi-mediated knockdown results in sterility (PubMed:16710447). RNAi-mediated knockdown in a him-8 mutant background results in no deposition of dimethylated 'Lys-9' of histone H3 (H3K9me2) on asynapsed chromosome pairs (PubMed:21909284). {ECO:0000269|PubMed:16710447, ECO:0000269|PubMed:17506990, ECO:0000269|PubMed:21909284}.