| 172664 | G5EEW6 | SIG7_CAEEL | Peptidyl-prolyl cis-trans isomerase sig-7 (EC 5.2.1.8) (Cyclophilin-like protein sig-7) (Silencer in germline 7) | DISRUPTION PHENOTYPE | Lethal during the early stages of larval development. RNAi-mediated knockdown results in 95% embryonic lethality with 86.15% of embryos exhibiting gastrulation defects with decreased expression of genes involved in gastrulation, and an increased abundance of unspliced RNAs, decreased levels of phosphorylated ama-1 at the 3' end of genes and decreased histone H3 modifications, which mark transcription elongation, in embryos. Rare survivors of lethality have multiple developmental defects in the soma and germline including a protruding vulva, multiple vulvae and failure to transition from spermatogenesis to oogenesis (also called masculinization of the germline or Mog phenotype). {ECO:0000269|PubMed:27541139}. |