| 172802 | P90916 | LIN53_CAEEL | Probable histone-binding protein lin-53 (Abnormal cell lineage protein 53) (Synthetic multivulva protein p48) | DISRUPTION PHENOTYPE | Decreased protein levels of DRM complex components including lin-9, lin-37, lin-52 and lin-54 (PubMed:17075059). Double knockout with the programmed cell death regulator mcd-1 results slow larval growth (PubMed:17237514). RNAi-mediated knockdown results in embryonic lethality (PubMed:9875852, PubMed:26904949). RNAi-mediated knockdown leads to a reduction of hcp-3 and his-1 protein levels and to a depletion of hcp-3 on centromeres and a reduction of H3K27me3 levels on metaphase chromosomes (PubMed:26904949). RNAi-mediated knockdown results in chromosome segregation defects during mitosis (PubMed:25446273, PubMed:26904949). {ECO:0000269|PubMed:17075059, ECO:0000269|PubMed:17237514, ECO:0000269|PubMed:25446273, ECO:0000269|PubMed:26904949, ECO:0000269|PubMed:9875852}. |