| 172891 | Q8WQ99 | KC1G_CAEEL | Casein kinase I gamma (CKI-gamma) (EC 2.7.11.1) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown in 1-cell embryos results in mislocalization of the pronuclei and the spindle towards the anterior part of the embryo, spindle instability, and failure of asymmetric cell division in 50 percent of embryos. In addition, spindle pulling forces are increased. par-2 and par-3 mediated embryo polarity is normal. Oocytes have increased cortical grp-1 and grp-2 localization. {ECO:0000269|PubMed:18694560}. |