| 173007 | Q967F4 | HMR1_CAEEL | Cadherin-related hmr-1 (Protein Hammerhead) | DISRUPTION PHENOTYPE | Embryonic lethal (PubMed:20689042, PubMed:25850673). Hammerhead phenotype characterized by morphogenetic defects before the start of body elongation, due to improper closure of hypodermis (PubMed:9531567, PubMed:25850673). Humpback phenotype with embryos containing dorsal humps (PubMed:20689042). Embryos also exhibit defective actin structures including loss of actin at cell-cell junctions and detached thick actin bundles called circumferential filament bundles that insert at right angles to junctional actin (PubMed:20689042). RNAi-mediated knockdown results in ingression defects in primordial germ cells (PubMed:22675206). {ECO:0000269|PubMed:20689042, ECO:0000269|PubMed:22675206, ECO:0000269|PubMed:25850673, ECO:0000269|PubMed:9531567}. |