Mine Disruption Phenotype

Gene Info

  • Species:Worm (Caenorhabditis elegans)
  • GeneID:173128
  • Symbol:dlk-1
  • Description:Mitogen-activated protein kinase kinase kinase dlk-1
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Gene ID Entry Entry Name Protein Name Type Information
173128 O01700 DLK1_CAEEL Mitogen-activated protein kinase kinase kinase dlk-1 (EC 2.7.11.25) (DAP kinase-like kinase) (Death-associated protein kinase-like kinase) DISRUPTION PHENOTYPE Overcome the lack of synaptogenesis caused by the loss of rpm-1 ubiquitin ligase activity (PubMed:17698012). Defects in axonal microtubule development (PubMed:19164707, PubMed:23000142). Double knockout with dlk-1 also suppresses the eva-1 receptor expression defect in the madd-3 single knockout (PubMed:27123983). Triple knockout with madd-3 and unc-54 results in paralysis (as in the unc-54 single knockout), and suppresses the lethality phenotype in the double madd-3 and unc-54 mutant (PubMed:27123983). {ECO:0000269|PubMed:17698012, ECO:0000269|PubMed:19164707, ECO:0000269|PubMed:23000142, ECO:0000269|PubMed:27123983}.