Mine Disruption Phenotype

Gene Info

  • Species:Worm (Caenorhabditis elegans)
  • GeneID:173788
  • Symbol:hlh-1
  • Description:Myoblast determination protein 1 homolog
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Gene ID Entry Entry Name Protein Name Type Information
173788 P22980 MYOD1_CAEEL Myoblast determination protein 1 homolog (MyoD protein 1) (Helix-loop-helix protein 1) DISRUPTION PHENOTYPE RNAi-mediated knockdown results in a low frequency of embryonic lethality, with embryos arresting paralyzed at the two-fold stage; increases in frequency significantly on an hnd-1 or unc-120 mutant background (PubMed:15892873). Many embryos that survive to hatch become uncoordinated, dumpy larvae (PubMed:15892873). Double RNAi-mediated knockdown with sem-2 results in no sex myoblast production (PubMed:21307099). {ECO:0000269|PubMed:15892873, ECO:0000269|PubMed:21307099}.