| 173945 | P81299 | CDC14_CAEEL | Tyrosine-protein phosphatase cdc-14 (EC 3.1.3.48) (Cell division cycle-related protein 14) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown results in extra cell divisions in the vulval lineage, but does not result in defects in cytokinesis (PubMed:15247923, PubMed:21723944). RNAi-mediated knockdown decreases cki-1 expression in the nucleus of vulval precursor cells (PubMed:15247923). In contrasting studies RNAi-mediated knockdown results in embryonic lethality with the production of multinucleated embryos that exhibit cytokinesis failure during telophase, no central spindle formation, and failed localization of the spindle component zen-4 and its interacting partner air-2 at the spindle in either anaphase or telophase (PubMed:12213836). {ECO:0000269|PubMed:12213836, ECO:0000269|PubMed:15247923, ECO:0000269|PubMed:21723944}. |