| 174233 | Q05062 | CDC42_CAEEL | Cell division control protein 42 homolog (CDC42Ce) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype) (PubMed:21408209). RNAi-mediated knockdown in distal tip cells (DTC) causes additional turns during their migration (PubMed:19023419). RNAi-mediated knockdown in addition, causes a truncation of excretory canals associated with the formation of cysts and a reduced distribution of Golgi and ER components along the excretory canal length (PubMed:25743393). RNAi-mediated knockdown results in defective endocytosis by oocytes characterized by an accumulation of aggregated yolk protein in the pseudocoelomatic space, and accumulation of endocytic cargo protein mig-14 in late endosomes and expansion of recycling endosomes that express toca-1 and toca-2 (PubMed:19798448, PubMed:25775511). RNAi-mediated knockdown enhances the axon guidance defects in glia and sublateral neurons of the kpc-1 gk mutant, in which non-commissural interneurons AIY fail to extend dorsally and enter the nerve ring (PubMed:28846083). {ECO:0000269|PubMed:19023419, ECO:0000269|PubMed:19798448, ECO:0000269|PubMed:21408209, ECO:0000269|PubMed:25743393, ECO:0000269|PubMed:25775511, ECO:0000269|PubMed:28846083}. |