| 174305 | Q09499 | IRE1_CAEEL | Serine/threonine-protein kinase/endoribonuclease ire-1 (Inositol-requiring protein 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] | DISRUPTION PHENOTYPE | In combination with RNAi-mediated knockdown of atf-6, causes sluggish movement, arrested development at the L2 larval stage, and lethality soon thereafter; larvae have intestinal degeneration and develop many vacuoles in the intestinal cells (PubMed:16184190). In combination with RNAi-mediated knockdown of pek-1, larvae have intestinal degeneration and develop many vacuoles in the intestinal cells (PubMed:16184190). RNAi-mediated knockdown restores fertility, reduces the accumulation of unspliced tra-2 in the cytoplasm and suppresses germ line masculinization caused by RNAi-mediated knockdown of rnp-4/RBM8A (PubMed:23149939). {ECO:0000269|PubMed:16184190, ECO:0000269|PubMed:23149939}. |