| 174309 | P54812 | TERA2_CAEEL | Transitional endoplasmic reticulum ATPase homolog 2 (EC 3.6.4.6) (Cell division cycle-related protein 48.2) (p97/CDC48 homolog 2) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown causes embryonic lethality in 30-50 percent of embryos (PubMed:15716356). RNAi-mediated knockdown prevents ubxn-2 nuclear localization in the 2-cell embryo (PubMed:23649807). RNAi-mediated knockdown in an unc-45 (m94) mutant background, does not restore motility (PubMed:17369820). Simultaneous RNAi-mediated knockdown of cdc-48.1 causes embryonic lethality (PubMed:15716356, PubMed:16647269, PubMed:18097415, PubMed:18728180, PubMed:26842564). Defects in oocyte meiosis I progression (PubMed:17512499). Defects in embryo S phase DNA replication causing delays in cell cycle progression (PubMed:17512499, PubMed:18097415, PubMed:18728180, PubMed:21981920). At the end of mitosis, impairs chromatin decondensation and nuclear envelope re-assembly (PubMed:18728180, PubMed:18097415). In addition, abnormal accumulation of air-2 on mitotic chromatin and impaired air-2 activation (PubMed:18097415). Does not affect ER transition into sheet-like structures at the onset of embryonic mitosis (PubMed:15716356). Simultaneous RNAi-mediated knockdown of cdc-48.2 in young adults decreases lifespan, induces the unfolded protein response, increases overall levels of polyubiquitinated proteins, and impairs the degradation of misfolded ER proteins (PubMed:16647269, PubMed:17825049, PubMed:17369820, PubMed:21317884, PubMed:22768338). Causes defects in germline development (PubMed:20977550). {ECO:0000269|PubMed:15716356, ECO:0000269|PubMed:16647269, ECO:0000269|PubMed:17369820, ECO:0000269|PubMed:17512499, ECO:0000269|PubMed:17825049, ECO:0000269|PubMed:18097415, ECO:0000269|PubMed:18728180, ECO:0000269|PubMed:20977550, ECO:0000269|PubMed:21317884, ECO:0000269|PubMed:21981920, ECO:0000269|PubMed:22768338, ECO:0000269|PubMed:23649807, ECO:0000269|PubMed:26842564}. |