Mine Disruption Phenotype

Gene Info

  • Species:Worm (Caenorhabditis elegans)
  • GeneID:174388
  • Symbol:etc-1
  • Description:E3 ubiquitin-protein ligase etc-1
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Gene ID Entry Entry Name Protein Name Type Information
174388 O17736 ETC1_CAEEL E3 ubiquitin-protein ligase etc-1 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase) DISRUPTION PHENOTYPE RNAi-mediated knockdown causes a reduction in progeny viability. ify-1 and cyb-1 accumulate in the cytoplasm during meiosis II. Also extents the length of meiosis II and causes retention of rec-8, a component of the cohesin complex, at sister chromatid cohesion. Causes a delay in oocyte budding. {ECO:0000269|PubMed:23578927}.