Mine Disruption Phenotype

Gene Info

  • Species:Worm (Caenorhabditis elegans)
  • GeneID:174431
  • Symbol:tomm-40
  • Description:Mitochondrial import receptor subunit TOM40 homolog
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Gene ID Entry Entry Name Protein Name Type Information
174431 Q18090 TOM40_CAEEL Mitochondrial import receptor subunit TOM40 homolog (Translocase of outer membrane 40 kDa subunit homolog) DISRUPTION PHENOTYPE Mutants arrest during the larval developmental stage. Impaired mitochondrial homeostasis with the up-regulation of the mitochondrial unfolded protein chaperone hsp-6. RNAi-mediated knockdown results in embryonic lethality or larval lethality between the L1 and L3 stage of larval development. Surviving progeny are growth retarded. No localization of the mitochondrial targeted protein nnt-1 to the mitochondria of intestinal cells. {ECO:0000269|PubMed:21264209}.