| 174436 | D0VWM8 | TADBP_CAEEL | Tar DNA-binding protein homolog 1 | DISRUPTION PHENOTYPE | Increased lifespan, slower growth rate, reduced egg-laying and reduced fertility (PubMed:22232551, PubMed:22792076). Defective locomotion and chemotaxis (PubMed:22232551, PubMed:25391662). Increased sensitivity to osmotic and oxidative stress (PubMed:22792076). Increased intronic A-to-I RNA editing and splicing abnormalities, which may contribute to the increased accumulation of double-stranded RNA observed in the nucleus of multiple tissues including gut, muscle and the anterior head region (PubMed:25391662). {ECO:0000269|PubMed:22232551, ECO:0000269|PubMed:22792076, ECO:0000269|PubMed:25391662}. |