| 174447 | Q22717 | HLH3_CAEEL | Helix-loop-helix protein 3 | DISRUPTION PHENOTYPE | Egg-laying defective (PubMed:18586090). Reduced expression of the tryptophan hydroxylase tph-1 which leads to reduced production of the neurotransmitter serotonin in the hermaphrodite-specific motor neurons (HSN) (PubMed:18586090). Inappropriate lateral projection of HSN axons (PubMed:18586090). Lack of netrin receptor unc-40 expression in a subset of HSN and VC motor neurons (PubMed:18586090). RNAi-mediated knockdown prevents cell death of a subset of the serotonergic neurosecretory motor (NSM) neuron sister cells, and survival of NSM sister cells is increased in an hlh-2 mutant background (PubMed:12874127). {ECO:0000269|PubMed:12874127, ECO:0000269|PubMed:18586090}. |