| 174531 | O18209 | PMY13_CAEEL | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3 (EC 2.7.11.1) (Lethal protein 37) (Myt1 kinase) | DISRUPTION PHENOTYPE | Worms exhibit oocytes that mature prematurely (also known as the Emo phenotype) and chromosomes that appear condensed (PubMed:16421191). Subcellular defects include irregular perinuclear foci in oocytes (PubMed:16421191). RNAi-mediated knockdown results in an accumulation of damaged, compressed, polyploid oocytes in the uterus (PubMed:11702779). RNAi-mediated knockdown in a double oma-1 and oma-2 knockout background allows for the progression of meiosis beyond the prophase stage and oocyte maturation, but these oocytes cannot be fertilized (PubMed:11702779). RNAi-mediated knockdown in a cdc-25.2 mutant background suppresses the defect in intestinal cell divisions in the cdc-25.2 single mutant (PubMed:27104746). {ECO:0000269|PubMed:11702779, ECO:0000269|PubMed:16421191, ECO:0000269|PubMed:27104746}. |