| 174552 | Q22024 | EGL43_CAEEL | Zinc finger protein egl-43 (Egg-laying defective protein 43) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown causes defects in anchor cell (AC) and ventral uterine (VU) precursor cell specification and AC invasion in the larval L3 and L4 stages (PubMed:17215301, PubMed:17573066). RNAi-mediated knockdown on a lin-12 mutant background reverses the AC-deficient phenotype (PubMed:17215301). RNAi-mediated knockdown reduces expression of zmp-1, cdh-3 and him-4 in the AC (PubMed:17215301, PubMed:17573066). RNAi-mediated knockdown reduces expression of fos-1a in the anchor cell (AC) approximately three-fold (PubMed:32203506). RNAi-mediated knockdown causes defects in vulval morphogenesis (PubMed:17573066). {ECO:0000269|PubMed:17215301, ECO:0000269|PubMed:17573066, ECO:0000269|PubMed:32203506}.; DISRUPTION PHENOTYPE: [Isoform a]: RNAi-mediated knockdown causes defects in anchor cell (AC) invasion, including increased CDK activity and re-entry of the AC into the cell cycle, resulting in the presence of two or more AC. {ECO:0000269|PubMed:17573066, ECO:0000269|PubMed:32203506}.; DISRUPTION PHENOTYPE: [Isoform b]: No defects in anchor cell (AC) invasion or arrest in G1 seen upon RNAi-mediated knockdown. {ECO:0000269|PubMed:32203506}. |