| 174586 | Q22070 | PLCG_CAEEL | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma plc-3) (Phospholipase C-gamma plc-3) (PLC-gamma plc-3) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown causes sterility resulting from impaired spermatheca dilatation causing a defect in ovulation, and a severe decrease in sheath cell basal and peak ovulatory contractions (PubMed:15194811, PubMed:18369461). The few embryos laid are arrested at the embryonic stage (PubMed:18369461). Cycles of posterior body wall muscle contractions are prolonged and arrhythmic resulting in a defecation defect (PubMed:16186564). Ca(2+) oscillations in intestinal cells are arrhythmic and the whole cell current amplitude is severely reduced (PubMed:16186564, PubMed:19923421). RNAi-mediated knockdown in males causes an increase in spontaneous muscle seizures in the absence of food in an unc-103 mutant background (PubMed:18604269). Ca(2+) transient increase and avoidance behavior are defective in response to nose touch but not to benzaldehyde (PubMed:19730689). nlp-29 expression is abrogated following fungal infection by D.coniospora and severely reduced following physical injury (PubMed:19380113). {ECO:0000269|PubMed:15194811, ECO:0000269|PubMed:16186564, ECO:0000269|PubMed:18369461, ECO:0000269|PubMed:18604269, ECO:0000269|PubMed:19380113, ECO:0000269|PubMed:19730689, ECO:0000269|PubMed:19923421}. |