| 174624 | P54811 | TERA1_CAEEL | Transitional endoplasmic reticulum ATPase homolog 1 (EC 3.6.4.6) (Cell division cycle-related protein 48.1) (p97/CDC48 homolog 1) | DISRUPTION PHENOTYPE | RNAi-mediated knockdown causes partial embryonic lethality (PubMed:15716356, PubMed:18854144). Impairs response to ER stress (PubMed:18458060). Abnormal accumulation of myosin chaperone unc-45 in body wall muscles (PubMed:17369820). RNAi-mediated knockdown in an unc-45 (m94) mutant background, restores motility (PubMed:17369820). Simultaneous RNAi-mediated knockdown of cdc-48.2 in embryos causes embryonic lethality (PubMed:15716356, PubMed:16647269, PubMed:18097415, PubMed:18854144, PubMed:18728180). Defects in oocyte meiosis I progression (PubMed:17512499). Defects in embryo S phase DNA replication causing delays in cell cycle progression (PubMed:17512499, PubMed:18728180, PubMed:21981920, PubMed:26842564, PubMed:28368371). At the end of mitosis, impairs chromatin decondensation and nuclear envelope re-assembly (PubMed:18728180, PubMed:18854144, PubMed:18097415). In addition, abnormal accumulation of air-2 on mitotic chromatin and impaired air-2 activation (PubMed:18097415). Does not affect ER transition into sheet-like structures at the onset of embryonic mitosis (PubMed:15716356). Simultaneous RNAi-mediated knockdown of cdc-48.2 in young adults decreases lifespan, induces the unfolded protein response, increases overall levels of polyubiquitinated proteins, and impairs the degradation of misfolded ER proteins (PubMed:16647269, PubMed:17825049, PubMed:17369820, PubMed:21317884, PubMed:22768338). Causes defects in germline development (PubMed:20977550). In an atx-3 (gk193) mutant background, causes a 50 percent increase in longevity, a delay in age-related muscle degeneration and resistance to oxidative and heat stresses (PubMed:21317884). {ECO:0000269|PubMed:15716356, ECO:0000269|PubMed:16647269, ECO:0000269|PubMed:17369820, ECO:0000269|PubMed:17512499, ECO:0000269|PubMed:17825049, ECO:0000269|PubMed:18097415, ECO:0000269|PubMed:18458060, ECO:0000269|PubMed:18728180, ECO:0000269|PubMed:18854144, ECO:0000269|PubMed:20977550, ECO:0000269|PubMed:21317884, ECO:0000269|PubMed:21981920, ECO:0000269|PubMed:22768338, ECO:0000269|PubMed:26842564, ECO:0000269|PubMed:28368371}. |