| 174739 | B7WN72 | SHANK_CAEEL | Protein shank | DISRUPTION PHENOTYPE | Animals are viable, but produce a reduced brood size, have a prolonged defecation cycle and a reduced pharyngeal pumping rate as compared to wild-type (PubMed:21191812). Reduced male fertility which may be due to irregular male mating behavior and defective sperm function (PubMed:21191812). Reduced cell surface abundance of the L-type egl-19 calcium channel in body wall muscles, which results in a 20% decrease in Ca(2+) current density (PubMed:28477407). In response to the nicotinic acetylcholine agonist levamisole, there is reduced expression of genes such as gem-4 (PubMed:28477407). Irregular postsynaptic transmission at neuromuscular junctions characterized by larger stimulus-evoked excitatory postsynaptic currents as compared to wild-type (PubMed:28477407). RNAi-mediated knockdown results in viable animals with no visible phenotype (PubMed:15013747). However, there is a slight reduction in brood size, but there are no visible defects in terms of embryonic viability, growth or morphology in their resulting progeny (PubMed:15013747). RNAi-mediated knockdown in an itr-1(sa73) loss of function mutant background results in a longer defecation cycle as compared to the itr-1 single mutant (PubMed:15013747). {ECO:0000269|PubMed:15013747, ECO:0000269|PubMed:21191812, ECO:0000269|PubMed:28477407}. |