| 174776 | G5EG17 | SMC6_CAEEL | Structural maintenance of chromosomes protein 6 homolog smc-6 | DISRUPTION PHENOTYPE | Reduced fecundity and transgenerational sterility (PubMed:20661436). Increased germ cell apoptosis and hypersensitivity to ultraviolet and ionizing radiation and hydroxyurea-induced replication stress (PubMed:20661436, PubMed:24424777). Increased rad-51 foci in the mitotic and meiotic germline on autosomes, but not on X chromosomes (PubMed:20661436, PubMed:27010650, PubMed:24424777, PubMed:24939994). Chromosome fragmentation defects and unresolved diakinesis chromosomes in meiotic oocytes (PubMed:20661436, PubMed:27010650). Impaired DNA replication in germ cells (PubMed:24424777). Accumulation of brd-1 on chromosomes in mitotic germ cells (PubMed:24424777). In a him-3 mutant background, increased rad-51 foci and chromosome fragmentation (PubMed:20661436). RNAi-mediated knockdown of syp-2 leads to an increase of chromosome fragmentation (PubMed:20661436). In a him-6 mutant background, leads to synergistic lethality (PubMed:27010650). In a fem-3 or him-8 mutant background, RNAi-mediated knockdown leads to increased fragmentation of autosomes and asynapsed X chromosomes but not of X chromosomes in males (PubMed:24939994). {ECO:0000269|PubMed:20661436, ECO:0000269|PubMed:24424777, ECO:0000269|PubMed:24939994, ECO:0000269|PubMed:27010650}. |