| 175007 | G5EBM1 | CSP1_CAEEL | Caspase A (EC 3.4.22.36) [Cleaved into: Caspase A subunit p16; Caspase A subunit p14] | DISRUPTION PHENOTYPE | Survival of touch neurons and several pharyngeal cells is not affected during development and no extra pharyngeal cells caused by impaired apoptosis are produced (PubMed:23505386). Basal and ionizing radiation-induced germline apoptosis are normal (PubMed:23505386). In a ced-3 n2427 mutant background, more animals have the M4 sister cell that survives (PubMed:23505386). In a csp-3 n4872, csp-2 n4871 and ced-3 n3692 mutant background where the canonical apoptotic pathway is impaired, 16 percent of animals have still 1 or more cell corpses that are morphologically apoptotic and are internalized by engulfing cells (PubMed:23505386). In addition, apoptosis of the male linker cell occurs normally (PubMed:23505386). RNAi-mediated knockdown causes a 50 percent inhibition of Mn(2+)-induced dopaminergic CEP neuron degeneration (PubMed:23721876). {ECO:0000269|PubMed:23505386, ECO:0000269|PubMed:23721876}. |