| 175080 | Q9U297 | KDM4_CAEEL | Lysine-specific demethylase 4 (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 2) (ceJMJD2) ([histone H3]-trimethyl-L-lysine(36) demethylase 4) ([histone H3]-trimethyl-L-lysine(9) demethylase 4) | DISRUPTION PHENOTYPE | Increased H3 'Lys-9' and 'Lys-36' trimethylation levels on meiotic chromosomes leading to trigger p53-dependent germline apoptosis (PubMed:16603238). In spr-5 null mutants, suppresses the progressive sterility over generations which is seen in spr-5 mutants (PubMed:24685137). RNAi-mediated knockdown results in extended lifespan (PubMed:22212395). {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:22212395, ECO:0000269|PubMed:24685137}. |